F132
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F132
Sigma
Fluoxetine hydrochloride
solid
| Synonym: | LY-110,140 hydrochloride, Prozac®, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride |
| CAS Number: | 56296-78-7 |
| Linear Formula: | C17H18F3NO · HCl |
| Molecular Weight: | 345.79 |
| EC Number: | 260-101-2 |
| MDL number: | MFCD00214288 |
| PubChem Substance ID: | 24278096 |
Description
| Biochem/physiol Actions | Selective serotonin reuptake inhibitor; antidepressant. |
| Legal Information | Sold under license from Eli Lilly and Company. |
| Prozac is a registered trademark of Eli Lilly and Co. |
Properties
| form | solid |
| color | white |
| solubility | H2O: 4 mg/mL |
| DMSO: >5 mg/mL | |
| Gene Information | human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-38-41 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| RTECS | UI4050000 |
References
| reference | Wong, D.T., et al., Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci. 57, 411-441, (1995) |
| Ni, Y.G., et al., Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). Proc. Natl. Acad. Sci. U. S. A. 94, 2036-2040, (1997) | |
| Gobert, A., et al., Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY 100,365 and GR 127,935. J. Neurochem. 68, 1159-1163, (1997) |
